Author's response to reviews Title:Fibrinogen concentrate versus placebo for treatment of postpartum haemorrhage: study protocol for a randomised controlled trial Authors:
نویسندگان
چکیده
Nadine Aawar ([email protected]) Raza Alikhan ([email protected]) Daniel Bruynseels ([email protected]) Rebecca Cannings-John ([email protected]) Rachel Collis ([email protected]) John Dick ([email protected]) Christopher Elton ([email protected]) Roshan Fernando ([email protected]) Judith Hall ([email protected]) Kerry Hood ([email protected]) Nicki Lack ([email protected]) Shuba Mallaiah ([email protected]) Helena Maybury ([email protected]) Jacqueline Nuttall ([email protected]) Shantini Paranjothy ([email protected]) Rachel Rayment ([email protected]) Alexandra Rees ([email protected]) Julia Sanders ([email protected]) Julia Townson ([email protected]) Andrew Weeks ([email protected]) Peter Collins ([email protected])
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Fibrinogen concentrate versus placebo for treatment of postpartum haemorrhage: study protocol for a randomised controlled trial
BACKGROUND Postpartum haemorrhage (PPH) is a major cause of maternal morbidity. Bleeding is caused by a combination of physical causes, such as failure of the uterus to contract or operations, and is made worse by impairment of the blood clotting system. A number of studies have shown that low levels of the blood clotting factor fibrinogen are associated with progression of bleeding, the need f...
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The FIB-PPH trial: fibrinogen concentrate as initial treatment for postpartum haemorrhage: study protocol for a randomised controlled trial
BACKGROUND Postpartum haemorrhage (PPH) remains a leading cause of maternal mortality worldwide. In Denmark 2% of parturients receive blood transfusion. During the course of bleeding fibrinogen (coagulation factor I) may be depleted and fall to critically low levels, impairing haemostasis and thus worsening the ongoing bleeding. A plasma level of fibrinogen below 2 g/L in the early phase of pos...
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